Turmeric: Beyond Anti-Inflammation & Anti-Oxidation

Turmeric is a well-known ancient herbal medicine from the rhizome of Curcuma longa, a member of ginger family, and commonly found in health supplements for knee pain. It possesses remarkable health-promoting properties, thanks to its well-known anti-inflammatory and antioxidant properties, along with many other physiological benefits. Mounting evidence proves the healing properties of turmeric is attributed to its active compounds – curcuminoids, which is now used in many health supplements.

Curcuminoids are known to suppress inflammation by inhibiting NF-kB, a transcription factor which triggers a cascade of undesirable inflammatory responses in the body. NF-kB is implicated in a host of chronic diseases ranging from cardiovascular diseases to cancer. As a potent antioxidant, curcuminoids effectively to counteract free radicals in two ways: prevention of free radical formation; and quenching of preformed radicals.

Arthritis management

Turmeric offers safe and effective therapeutic benefits in alleviating inflammation and pain associated with osteoarthritis and rheumatoid arthritis. Unlike NSAIDs, this natural COX-2 inhibitor does not cause undesirable gastrointestinal side effects. This makes them perfect to be used in joint care supplement for knee pain.

Cardiovascular support

Turmeric extract shows promising results in lowering serum levels of LDL-cholesterol and triglycerides, thus reducing the risk factors for coronary heart diseases.

Blood sugar management

Many studies have suggested that turmeric helps in managing blood sugar levels. It increases the production of insulin and protects the pancreatic cells from damage caused by oxidative agents.

Brain function

Curcumin has been shown to prevent the formation and break down amyloid-beta plaques associated with Alzheimer’s disease.

Gastrointestinal health

Turmeric extract helps mprove symptoms of irritable bowel syndrome (IBS) such as gas, diarrhea, constipation, etc.

Anti-allergic

Curcuminoids are used to alleviate symptoms of allergies by inhibiting the release of histamine form mast cells.

Cancer prevention

Curcuminoids act by interfering with signalling mechanisms (critical for tumour growth), regulation of apoptosis (cell death), and tumour angiogenesis (new blood vessel formation which feeds tumours).

Chemo-preventive effects

Curcumin has recently received increased attention in protecting normal tissues from chemotherapy-induced toxicity. It may also enhance the therapeutic efficacy of many anti-cancer drugs and reduce their side effects through pharmacological and pharmacokinetic interactions.

Sources:

Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016; 19(8):717-729.
Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MR. The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial. Iranian Journal of Pharmaceutical Research. 2015;14(2):479-486.
Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomedicine & Pharmacotherapy. 2016;82:578-582.
Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Annals of Indian Academy of Neurology. 2008;1(11):13-19.
Tomeh MA, Hadianamrei R, Zhao X. A Review of Curcumin and Its Derivatives as Anticancer Agents. International Journal of Molecular Sciences. 2019;20:1033.
Liu Z, Huang P, Law, Tian H, Leung L, Xu C. Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects. Frontiers in Pharmacology. 2018;9:1374.
Kurup VP, Barrios CS. Immunomodulatory effects of curcumin in allergy. Nutr. Food Res. 2008;52:1031-1039.
Moloughney S. (2019) Curcumin: Traditional Roots Intertwined with Modern Science. Retrieved from https://www.nutraceuticalsworld.com/

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Turmeric: Beyond Anti-Inflammation & Anti-Oxidation

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